Synthesis of 5-Deoxy-5-phenylphosphino- and 5-Phenylphosphinyl-D-glucopyranoses
نویسندگان
چکیده
منابع مشابه
ATTEMPTED SYNTHESIS OF 5' - DEOXY - 5' - PHOSPHONO - ISOCYTIDINE SYNTHESIS OF PHOSPHONIC ACID DERIVATIVES OF ACYCLO - NUCLEOSIDES. PREPARATION OF 1- ?- D- ARABINOFURANOSYL PYRIMIDINES
The synthesis of 5' - deoxynucleoside 5' - phosphonates which contains a 5' - CP bond in place of the 5' -COP bond of the naturally occuring nucleotides is described. The preparation of phosphonate derivatives of acyclo - nucleosides and a simple method for the conversion of 1-? -D-ribofuranosyl pyrimidines to the corresponding 1-? -D-arabinofuranosyl pyrimidines are also explained
متن کاملConversion of 5'-deoxy-5'-methylthioadenosine and 5'-deoxy-5'-methylthioinosine to methionine in cultured human leukemic cells.
5'-Deoxy-5'-methylthioadenosine and 5'-deoxy-5'-methylthioinosine, which are metabolized to the methionine precursor, 5-methylthioribose-1-phosphate, by 5'-deoxy-5'-methylthioadenosine phosphorylase and purine nucleoside phosphorylase, respectively, can serve as sources of methionine for cultured HL-60 promyelocytic leukemia cells. CCRF-CEM T-cell leukemia cells, which lack 5'-deoxy-5'-methylth...
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the synthesis of 5' - deoxynucleoside 5' - phosphonates which contains a 5' - cp bond in place of the 5' -cop bond of the naturally occuring nucleotides is described. the preparation of phosphonate derivatives of acyclo - nucleosides and a simple method for the conversion of 1-? -d-ribofuranosyl pyrimidines to the corresponding 1-? -d-arabinofuranosyl pyrimidines are also ex...
متن کاملDesign, synthesis, and biological evaluation of novel human 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP) substrates.
The structure-based design, chemical synthesis, and biological evaluation of novel MTAP substrates are described. These compounds incorporate various C5'-moieties and are shown to have different k(cat)/K(m) values compared with the natural MTAP substrate (MTA).
متن کاملDifferential Neuroprotective Effects of 5′-Deoxy-5′-Methylthioadenosine
BACKGROUND 5'-deoxy-5'-methylthioadenosine (MTA) is an endogenous compound produced through the metabolism of polyamines. The therapeutic potential of MTA has been assayed mainly in liver diseases and, more recently, in animal models of multiple sclerosis. The aim of this study was to determine the neuroprotective effect of this molecule in vitro and to assess whether MTA can cross the blood br...
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ژورنال
عنوان ژورنال: Bulletin of the Chemical Society of Japan
سال: 1991
ISSN: 0009-2673,1348-0634
DOI: 10.1246/bcsj.64.2398